BACKGROUND: Dementia with Lewy bodies (DLB) and Parkinson\'s disease dementia (PDD) are the two most common types of dementing neurodegenerative disease after Alzheimer\'s disease (AD). Both of these conditions are michael Kors Outlet Singapore often diagnosed late or not at all.METHODS: Selective literature review.RESULTS: The severe cholinergic and dopaminergic deficits that are present in both DLB and PDD produce not only motor manifestations, but also cognitive deficits, mainly in the executive and visual-constructive areas, as well as psychotic manifestations such as visual hallucinations, delusions, and agitation. The intensity of these manifestations can fluctuate markedly over the course of the day, particularly in DLB. Useful tests for differential diagnosis include magnetic resonance imaging and electroencephalography; in case of clinical uncertainty, nuclear medical procedures and cerebrospinal fluid analysis can be helpful as well. Neuropathological studies have revealed progressive alpha-synuclein aggregation in affected areas of the brain. In DLB, beta-amyloid abnormalities are often seen as well.CONCLUSION: DLB should be included in the differential diagnosis of early dementia. If motor manifestations arise michael Kors Handbags within one year (DLB), dopaminergic treatment should be initiated. On the other hand, patients with Parkinson\'s disease should undergo early screening for signs of dementia so that further diagnostic and therapeutic steps can be taken in timely fashion, as indicated. Cholinesterase inhibitors are useful for the treatment of cognitive deficits and experiential/behavioral disturbances in both DLB (off-label indication) and PDD (approved indication).Comment inThe investigation and differential diagnosis of dementias. [Dtsch Arztebl Int. 2010]The investigation and differential diagnosis of dementias.Mahlberg michael Kors Malaysia R. Dtsch Arztebl Int. 2010 Oct; 107(39):675-6. Epub 2010 Oct 1.Lewy body and parkinsonian dementia: common, but often misdiagnosed Michael Kors Singapore conditions: Evidence is not satisfactory. [Dtsch Arztebl Int. 2011]Lewy body and parkinsonian dementia: common, but often misdiagnosed conditions: Evidence is not satisfactory.Landau R. Dtsch Arztebl Int. 2011 Feb; 108(8):131; author reply 132. Epub 2011 Feb 25.Lewy body and parkinsonian dementia: common, but often misdiagnosed conditions: Hydrocephalus should not be forgotten. [Dtsch Arztebl Int. 2011]Lewy body and parkinsonian dementia: common, but often misdiagnosed conditions: Hydrocephalus should not be forgotten.Vahl CF. Dtsch Arztebl Int. 2011 Feb; 108(8):131; author reply 132. Epub 2011 Feb 25.